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Development and Performance of Pharmacodynamic Assays to Demonstrate Proof-of-Mechanism for IRAK4 Degraders in a Phase1 Study
October 26, 2022
5th Annual Targeted Protein Degradation (TPD) Summit
View Presentation
Area of Focus
Immunology
Programs
IRAK4 (KT-474)
Indications
Atopic Dermatitis (AD)
Hidradenitis Suppurativa (HS)
Development Stage
Clinical Data
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November 13, 2023
Nature Medicine: IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial
Lindsay Ackerman, Gerard Acloque, Sandro Bacchelli, Howard Schwartz, Brian J. Feinstein, et al.
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IRAK4 Degradation vs Inhibition
IRAK4 Program Background
Atopic Dermatitis (AD)
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Safety and Efficacy of IRAK4 Degrater KT-474 (SAR444656) for Hidradenitis Suppurativa and Atopic Dermatitis
European Academy of Dermatology & Venereology (EADV) Symposium 2023
Atopic Dermatitis (AD)
Hidradenitis Suppurativa (HS)
View Resource