June 1, 2022
Phase 1 Study of KT-333, a Targeted Protein Degrader of STAT3, in Patients with Relapsed or Refractory Lymphomas, Large Granular Lymphocytic Leukemia, and Solid Tumors
American Society of Clinical Oncology (ASCO) 2022 Annual Meeting
CTCL
LGL-L
PTCL
Solid Tumors
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June 1, 2022
Phase 1 Study of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates, in Adult Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma
American Society of Clinical Oncology (ASCO) 2022 Annual Meeting
MYD88 Tumors
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April 7, 2022
KT-253, a highly potent and selective heterobifunctional MDM2 degrader for the treatment of wildtype p53 tumors with superior potency and differentiated biological activity compared to small molecule inhibitors (SMI)
American Association for Cancer Research Annual Meeting
Liquid Tumors
Solid Tumors
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December 13, 2021
Selective STAT3 Degraders Dissect Peripheral T-Cell Lymphomas Vulnerabilities Empowering Personalized Regimens
The 63rd Annual ASH Meeting and Exposition
Liquid Tumors
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December 13, 2021
A First-in-Class STAT3 Degrader KT-333 in Development for Treatment of Hematologic Cancers
The 63rd Annual ASH Meeting and Exposition
Liquid Tumors
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November 12, 2021
Targeted STAT3 Degradation Leads to Remodeling of an Immunosuppressive Tumor Microenvironment and Subsequent Sensitization to Immune Checkpoint Inhibition
SITC 2021
Liquid Tumors
Solid Tumors
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October 27, 2021
Understanding PK/PD for Development of STAT3 Degraders in Oncology Indications
4th Annual TPD Summit
Liquid Tumors
Solid Tumors
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July 12, 2021
Targeting STAT3 with Selective Protein Degraders for the Treatment of PTCL
13th Annual T-Cell Lymphoma Forum
PTCL
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June 20, 2021
KT-413, a Novel IRAKIMiD Degrader of IRAK4 and IMiD Substrates, has a Differentiated MOA that Leads to Single-agent and Combination Regressions in MYD88MT Lymphoma Models
16th Annual International Conference on Malignant Lymphoma (ICML) Virtual Meeting
MYD88 Tumors
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April 10, 2021
Mechanisms Underlying Synergistic Activity of KT-413, a Targeted Degrader of IRAK4 and IMiD Substrates in Hematopoietic Cancers
American Association of Cancer Research (AACR) 2021 Annual Meeting
MYD88 Tumors
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