Resource Library

Discover Kymera’s research and resources on our exciting platform, pipeline, and additional cutting-edge technologies.

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Related Resources

October 27, 2021

Safety, PK and PD from Single Ascending Does Portion of KT-474 Phase 1 Trial in Healthy Volunteers

4th Annual TPD Summit
Atopic Dermatitis (AD) Hidradenitis Suppurativa (HS)
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October 26, 2021

TPD Workshop: De-risking Clinical Development of a Novel Protein Degrader

4th Annual TPD Summit
Atopic Dermatitis (AD) Hidradenitis Suppurativa (HS)
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September 21, 2021

Identification of Highly Potent and Selective Interleukin-1 Receptor Associates Kinase 4 (IRAK4) Degrader for the Treatment of Autoimmune Disease

European Protein Degradation Congress
Atopic Dermatitis (AD) Hidradenitis Suppurativa (HS)
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May 10, 2021

IRAK4 Degradation Abrogates Cytokine Release and Improves Disease Endpoints in Murine Models of IL-33/36- as well as Th17-driven Inflammation

American Association of Immunologists’ Virtual IMMUNOLOGY2021™ Annual Meeting
Atopic Dermatitis (AD) Hidradenitis Suppurativa (HS)
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May 3, 2021

Multiple Mediators of Inflammation Correlate with IRAK4 Expression in the Skin of Hidradenitis Suppurativa Patients and are Blocked by the IRAK4 Degrader KT-474 in TLR-activated Monocytes

Society for Investigative Dermatology (SID) 2021 Annual Meeting
Atopic Dermatitis (AD) Hidradenitis Suppurativa (HS)
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November 3, 2020

IRAK4 Degrader to Take on Innate Immunity

Mullard, A. IRAK4 degrader to take on innate immunity. Nat Biotechnol 38, 1221–1223 (2020)
Atopic Dermatitis (AD) Hidradenitis Suppurativa (HS)
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October 9, 2020

Interim results from non-interventional study to evaluate cutaneous and circulating biomarkers for a novel IRAK4-targeted therapeutic in patients with hidradenitis suppurativa

5th Annual Symposium on Hidradenitis Suppurativa Advances (SHSA)
Hidradenitis Suppurativa (HS)
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February 5, 2020

Identification of highly potent and selective Interleukin-1 receptor associated kinase 4 (IRAK4) degraders for the treatment of hidradenitis suppurativa

European Hidradenitis Suppurativa Foundation Scientific Conference
Hidradenitis Suppurativa (HS)
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November 8, 2019

A first-in-class selective and potent IRAK4 degrader demonstrates robust in vitro and in vivo inhibition of TLR/IL-1R activation and inflammation

American College of Rheumatology Annual Meeting
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