Vice President, Safety and Pharmacovigilance

<h3>Who we are:</h3> Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years.    <h3>How we work:</h3> <ul> <li>PIONEER: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.</li> <li>COLLABORATE: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.</li> <li>BELONG: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.</li> </ul>   <h3>How you’ll contribute:</h3> Kymera Therapeutics is seeking an innovative and collaborative leader to serve as Vice President, Safety and Pharmacovigilance. Reporting to the Chief Medical Officer, this individual will be responsible for the strategic oversight, execution, and management of global pharmacovigilance (PV) and risk management activities across Kymera’s pipeline. The VP will play a key role in fostering a culture of safety, ensuring compliance with global safety regulations, and guiding Kymera’s safety strategy in collaboration with internal and external stakeholders. This position requires a dynamic leader who can effectively engage with regulatory authorities, oversee pharmacovigilance operations, and provide safety leadership across clinical development programs. Key Responsibilities Strategic Leadership & Safety Governance: <ul> <li>Lead and oversee all pharmacovigilance and risk management activities for Kymera’s clinical programs.</li> <li>Foster a "safety by design" culture within Kymera to ensure the highest level of patient safety and regulatory compliance.</li> <li>Represent Kymera in interactions with health authorities, including preparing and presenting safety data in regulatory meetings.</li> <li>Provide strategic oversight for safety sections of regulatory filings, including BLA/NDA/MAA, public presentations, and key scientific articles.</li> <li>Participate in and lead Kymera’s Safety Review Committees, clinical trial-specific safety reviews, and, where applicable, data monitoring committees.</li> <li>Provide medical safety expertise and leadership across all clinical development activities, including protocols, CSRs, IBs, ICFs, and regulatory briefing books.</li> </ul> Operational & Regulatory Excellence: <ul> <li>Ensure compliance with global pharmacovigilance regulations (FDA, EMA, ICH, EU GVP, and other relevant agencies).</li> <li>Oversee signal detection, safety surveillance, and benefit-risk assessments, implementing risk mitigation strategies as needed.</li> <li>Direct the preparation and review of key safety documents, including DSURs, SUSARs, periodic and annual safety reports, and regulatory communications.</li> <li>Lead responses to safety questions from regulatory authorities, audits, and inspections while ensuring corrective actions are effectively implemented.</li> <li>Collaborate cross-functionally with Clinical, Medical Affairs, Regulatory, Quality, and Translational Sciences teams to drive safety initiatives.</li> <li>Manage and oversee internal and external PV resources, including CROs and safety service providers.</li> </ul> People & Organizational Leadership: <ul> <li>Mentor and develop a high-performing pharmacovigilance team, fostering a culture of continuous learning and operational excellence.</li> <li>Participate as a core member of Kymera’s senior leadership team, contributing to overall company strategy and risk management.</li> <li>Develop and manage PV budgets, ensuring alignment with corporate objectives.</li> <li>Drive innovation by monitoring industry best practices and recommending process improvements to enhance Kymera’s safety infrastructure.</li> </ul>   <h3>Skills and experience you’ll bring:</h3> <ul> <li>M.D. required with 10+ years of experience in pharmacovigilance, safety science, or related roles within the pharmaceutical/biotech industry.</li> <li>Expertise in global pharmacovigilance regulations, safety surveillance, and risk management strategies.</li> <li>Experience with regulatory authority interactions, safety database applications, and safety signal detection methodologies.</li> <li>Strong leadership skills with a proven track record of building and managing safety teams.</li> <li>Effective communicator with excellent written, verbal, and presentation skills.</li> <li>Ability to thrive in a fast-paced, high-growth environment, balancing multiple priorities while maintaining a strong commitment to ethical standards.</li> </ul>   <h3>Skills and experience not an exact match?:</h3> Go ahead and submit your resume (and a cover letter, if you’d like!).  If this role isn't right for you, we can keep you in mind for future opportunities.                                                                                                                                                                                        Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment.  All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.

Back to open positions