Director or Senior Director, Toxicology
<h3><strong>Who we are:</strong></h3>
<p>Kymera is a clinical-stage biotechnology company pioneering the field of targeting protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on delivering oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Kymera is also progressing degrader oncology programs that target undrugged or poorly drugged proteins to create new ways to fight cancer. Founded in 2016, Kymera has been recognized as one of Boston’s top places to work for the past several years. For more information about our science, pipeline, and people, please visit <a href="http://www.kymeratx.com">www.kymeratx.com.</a></p>
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<h3><strong>How we work:</strong></h3>
<ul>
<li><strong>PIONEER</strong>: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.</li>
<li><strong>COLLABORATE</strong>: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.</li>
<li><strong>BELONG</strong>: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.</li>
</ul>
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<h3><strong>How you’ll contribute:</strong></h3>
<ul>
<li>Provide expert support, guidance, and strategy on project safety assessments, with a specific focus on discovery & IND-stage small molecule projects.
<ul>
<li>Providing scientific and regulatory toxicology expertise to cross-functional project teams</li>
<li>Develop toxicology strategies and plans for programs in all stages of drug development</li>
</ul>
</li>
<li>Oversee toxicology and safety pharmacology studies at multiple Contract Research Organizations
<ul>
<li>Design and execute GLP, non-GLP, and investigative toxicology studies</li>
<li>Monitor toxicology studies for appropriate conduct, accuracy, and timely execution; review draft reports and ensure quality submission-ready documents for regulatory authorities</li>
<li>Proactively respond to study issues and resolve problems with study director</li>
</ul>
</li>
<li>Internal and external communication
<ul>
<li>Prepare verbal and written summaries for internal discussions. Work with the Preclinical Development team to develop optimal strategies to address specific safety issues and partner with project teams</li>
<li>Lead authorship of toxicology and/or safety pharmacology sections of various regulatory documents (e.g., pre-IND briefing documents, IND/CTA, IBs etc.)</li>
<li>Represent company at meetings with regulatory agencies</li>
<li>Present summary data to project teams and Kymera senior leadership</li>
</ul>
</li>
</ul>
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<h3><strong>Skills and experience you’ll bring:</strong></h3>
<ul>
<li>PhD in Toxicology or Pharmacology, DVM, or related field</li>
<li>A minimum of 5 years’ experience in the life science industry in a Toxicology or Pathology role and proven track record of conducting preclinical drug safety assessment studies, and ability to make sound risk assessments and represent toxicology perspectives on project teams and with external partners</li>
<li>Direct experience developing the toxicology strategy and data package supporting the clinical development of small molecule therapeutics</li>
<li>Demonstrated track record of toxicology leadership on multiple programs at early and late stages of development</li>
<li>Experience with EMA and FDA CTA/IND submissions and regulatory interactions</li>
<li>Experience partnering with internal stakeholders and colleagues to ensure comprehensive preclinical safety approaches are developed as part of the program strategy</li>
<li>Experience working with outsourced studies</li>
<li>Ability to perform in fast-paced and dynamic environment</li>
<li>Excellent communication and organizational skills and attention to detail</li>
</ul>
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<h3><strong>Skills and experience not an exact match?:</strong></h3>
<p>Go ahead and submit your resume (and a cover letter, if you’d like!). If this role isn't right for you, we can keep you in mind for future opportunities.</p>
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<p><strong><em><span class="ui-provider a b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak">Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.</span></em></strong></p>
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