Associate Scientist, Platform Biology
<h3><strong>Who we are:</strong></h3>
<p>Kymera is a clinical-stage biotechnology company pioneering the field of targeted protein degradation (TPD) to develop medicines that address critical health problems and have the potential to dramatically improve patients’ lives. Kymera is deploying TPD to address disease targets and pathways inaccessible with conventional therapeutics. Having advanced the first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in 2016, Kymera has been recognized as one of Boston’s top workplaces for the past several years. </p>
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<h3><strong>How we work:</strong></h3>
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<li><strong>PIONEER</strong>: We are courageous, resilient and rigorous in our mission to improve patients’ lives through our revolutionary degrader medicines.</li>
<li><strong>COLLABORATE</strong>: We value trust + transparency from everyone. Our goals are shared, our decisions data-driven and our camaraderie genuine.</li>
<li><strong>BELONG</strong>: We recognize our differences, inviting curiosity and inclusivity, so that our people are valued, seen, and heard.</li>
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<h3><strong>How you’ll contribute:</strong></h3>
<ul>
<li>Generate multiple cell models by shRNA and CRISPR KO/KI to enable development of next generation TPD technologies.</li>
<li>Develop quantitative cell-based assays to facilitate SAR and MOA studies for novel degraders.</li>
<li>Perform various plate-based assays to evaluate changes in biomarkers from primary human cells and tissue from animal models.</li>
<li>Maintain good written records of laboratory procedures and communicate research findings in cross-functional project team meetings.</li>
<li>Review literature and conference proceedings to identify emerging technologies/assays and execute exploratory efforts for internal validation.</li>
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<h3><strong>Skills and experience you’ll bring:</strong></h3>
<ul>
<li>BS or MS degree in Biology, Immunology, or related field with 3+ years of experience.</li>
<li>Extensive tissue culture experience with cell and molecular biology techniques including transient transfection, lentivirus handling, and stable cell line generation by shRNA, CRISPR KO/KI.</li>
<li>Exceptional skills in quantitative FACS analysis and high-throughput fluorescence microscopy and image analysis are highly desirable.</li>
<li>Proficient experience and technical expertise in performing and developing various plate-based assays including ELISA, MSD, and AlphaLISA, etc.</li>
<li>Independent mindset to execute experiments, analyze, and interpret results with minimal supervision while proactively seeking help and guidance.</li>
<li>Excellent organizational, verbal, and written communication skills and familiarity with electronic laboratory notebooks (ELN).</li>
<li>Expertise in immunology and cytokine biology is highly desired. Previous experience in TPD is desirable but not required.</li>
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<p><strong><em><span class="ui-provider a b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak">Kymera Therapeutics is proud to be an equal opportunity employer, seeking to create a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, creed, gender, national origin, age, disability, veteran status, pregnancy, sex, marital status, gender expression or identity, genetic information, sexual orientation, citizenship, or any other legally protected class.</span></em></strong></p>
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